Table 7.
The determination of coefficient (R2) and release exponent (n) values for in vitro release profiles of the market product (Exjade®) and DFX S-SNEDD formulations prepared by different carriers.
| Formulation | Zero Order | First Order | Higuchi Model | Hixon Crowell Model | Korsemeyer–Peppas Model | |
|---|---|---|---|---|---|---|
| R2 * | R2 * | R2 * | R2 * | R2 * | nValue | |
| Market product (Exjade®) | 0.459 | 0.657 | 0.762 | 0.531 | 0.842 ** | 1.323 |
| P6-40-US2 | 0.403 | 0.562 | 0.707 | 0.672 | 0.788 ** | 1.318 |
| P6-40-UFL2 | 0.65 | 0.881 | 0.859 | 0.642 | 0.914 ** | 1.385 |
| P6-40-Syloid | 0.479 | 0.725 | 0.775 | 0.847 | 0.848 ** | 1.31 |
* R2 (R squared) value is a statistical measure of how close the data to the fitted regression line for each model. ** Values in bold represent the highest r2 value for each formulation in comparison with different models.