Table 1.
Characteristics of patients at admission to emergency department stratified for platelet transfusion received during haemostatic resuscitation until 48 h after ICU admission.
| Demographics | Unmatched Population | Matched Population | ||||||
|---|---|---|---|---|---|---|---|---|
| No PC (n = 60) |
PC (n = 34) |
Estimate with 95% CI |
p Value | No PC (n = 43) |
PC (n = 19) |
Estimate with 95% CI |
p Value | |
| Age (years) | 40.5 (25.75–51.25) | 47.5 (26.25–58.75) | −3 (−10 to 4) | 0.3952 | 44 (30.5–51.5) | 54 (30–62) | −8 (−18 to 3) | 0.1343 |
| Male Sex | 49/60 (81.7%) | 21/34 (61.8%) | 0.37 (0.13 to 1.05) | 0.0484 | 33/43 (76.7%) | 13/19 (68.4%) | 0.66 (0.17 to 2.69) | 0.5378 |
| Time to ED (min) | 61.5 (40–90) | 59 (45.25–78.25) | 3.15 (−10 to 20) | 0.6508 | 58 (40–86) | 60 (42–76.5) | 0 (−18 to 20) | 0.9756 |
| ISS (pts) | 29 (24–36.5) | 42.5 (33.25–57) | −12 (−18 to −7) | <0.0001 | 34 (29–39.5) | 34 (29–38) | 0 (−5 to 4) | 0.8841 |
| AIS brain > 2 | 16/60 (26.7%) | 13/34 (38.2%) | 1.69 (0.63 to 4.57) | 0.2556 | 15/43 (34.9%) | 6/19 (31.6%) | 0.86 (0.22 to 3.08) | 1 |
| Systolic BP (mmHg) | 118 (93.75–140) | 90 (70.5–127.5) | 20 (2 to 34) | 0.0181 | 120 (100–135) | 120 (90.5–139.5) | 0 (−20 to 15) | 0.7827 |
| Heart rate (bts/min) | 92.5 (80.75–108.25) | 110 (85–116) | −10 (−20 to 1) | 0.0688 | 93 (82–108.5) | 100 (72–110) | 4 (−10 to 17) | 0.6349 |
| Blood pH | 7.33 (7.27–7.37) | 7.31 (7.17–7.36) | 0.04 (0 to 0.09) | 0.0679 | 7.31 (7.26–7.38) | 7.35 (7.32–7.37) | −0.03 (−0.07 to 0.02) | 0.219 |
| BD (mmol/L) | 3.7 (1.23–5.62) | 4.5 (3.23–9.35) | −1.8 (−3.6 to 0) | 0.05 | 4.7 (1.85–6.15) | 3.8 (2.15–4.85) | 0.8 (−0.9 to 2.4) | 0.2955 |
| Lactate (mmol/L) | 2.16 (1.44–2.8) | 2.33 (1.8–4.86) | −0.44 (−1.22 to 0.11) | 0.0875 | 2.44 (1.55–2.94) | 1.89 (1.55–2.33) | 0.33 (−0.11 to 0.78) | 0.1485 |
| Hemoglobin (g/dL) | 12.2 (10.85–13.4) | 10.05 (9–11.8) | 2 (1 to 2.9) | 0.0002 | 11.9 (10.6–12.9) | 10.5 (9.8–12.3) | 0.9 (−0.3 to 2) | 0.1364 |
| Fibrinogen (mg/dL) | 189.5 (166–222) | 171.5 (112.5–208.25) | 30.73 (3 to 58) | 0.029 | 205 (150–224.5) | 193 (171.5–225) | 2 (−22 to 30) | 0.9028 |
| Platelets (G/L) | 190.5 (156.75–217.25) | 166.5 (150–202.5) | 17 (−2 to 36) | 0.0848 | 189 (157.5–220.5) | 180 (151–215) | 11 (−13 to 37) | 0.3516 |
| PTI (%) | 69 (61.75–84.25) | 58.5 (44.25–68.25) | 14 (7 to 21) | 0.0002 | 69 (61.5–85) | 66 (58.5–74) | 5 (−3 to 13) | 0.151 |
| INR | 1.2 (1.1–1.33) | 1.4 (1.2–1.67) | −0.2 (−0.3 to −0.1) | 0.0004 | 1.2 (1.1–1.35) | 1.3 (1.2–1.4) | −0.1 (−0.1 to 0) | 0.2553 |
| aPTT (s) | 31.5 (27.75–33.25) | 37 (29.25–49) | −7 (−12 to −3) | 0.0004 | 32 (29–33.5) | 34 (28–37.5) | −2 (−5 to 2) | 0.3348 |
| ExCT (s) | 54 (51–63) | 64 (49–82) | −7 (−16 to 0) | 0.0552 | 56.5 (52–67.25) | 49 (47.5–64) | 5 (−1 to 10) | 0.0959 |
| ExMCF (mm) | 56 (50–59) | 54 (49.25–57) | 3 (−1 to 5) | 0.1195 | 57 (48.75–61.25) | 54 (53–57.5) | 1 (−3 to 5) | 0.6432 |
| FibA10 (mm) | 9 (6–11) | 8 (4.25–10) | 1 (0 to 3) | 0.0736 | 9 (5.75–12.25) | 9 (8–10.5) | −1 (−3 to 2) | 0.6716 |
Inf, infinitive means >4 at sofa score. mathematical correct is infinitive if it is >4. Binary data are presented as no./total no. (%) and continuous data as medians (IQR). Estimates are odds ratios for binary variables and estimated median differences for continuous variables. Differences between patients without and with platelet transfusion assessed by Fisher’s Exact Test for binary variables and Wilcoxon Rank Sum Test for continuous variables. PC, Platelet Concentrate; ISS, Injury Severity Score; AIS, Abbreviated Injury Severity Score; BP, Blood Pressure; BD, Base Deficit; PTI, Prothrombin Time Index (Quick); INR, International Normalised Ratio; aPTT, Activated Partial Thromboplastin Time; ExCT, Coagulation Time of ExTEM Assay; ExMCF, Maximum Clot Firmness of ExTEM Assay; FibA10, Fibrin Polymerization at 10 min.