Table 2.
Clinical outcome of patients receiving platelet transfusion or not during haemostatic resuscitation until 48 h after ICU admission.
| Organ Failure (SOFA > 2) | Unmatched Population | Matched Population | ||||||
|---|---|---|---|---|---|---|---|---|
| No PC (n = 60) |
PC (n = 34) |
Estimate with 95% CI |
p Value | No PC (n = 43) |
PC (n = 19) |
Estimate with 95% CI |
p Value | |
| Respiration | 18/60 (30%) | 18/34 (52.9%) | 2.6 (1.01 to 6.86) | 0.046 | 15/43 (34.9%) | 6/19 (31.6%) | 0.86 (0.22 to 3.08) | 1 |
| Coagulation | 4/60 (6.7%) | 20/34 (58.8%) | 19.15 (5.32–89.81) | <0.0001 | 2/43 (4.7%) | 13/19 (68.4%) | 39.99 (6.82–447.59) | <0.0001 |
| Liver | 0/60 (0%) | 6/34 (17.6%) | Inf (2.3 to Inf) | 0.0017 | 0/43 (0%) | 2/19 (10.5%) | Inf (0.43 to Inf) | 0.0904 |
| Cardiovascular | 48/60 (80%) | 34/34 (100%) | Inf (1.8 to Inf) | 0.0035 | 37/43 (86%) | 19/19 (100%) | Inf (0.54 to Inf) | 0.1647 |
| Central nervous system | 17/60 (28.3%) | 15/34 (44.1%) | 1.98 (0.75 to 5·26) | 0.1737 | 12/43 (27.9%) | 6/19 (31.6%) | 1.19 (0.3 to 4.39) | 0.77 |
| Renal | 1/60 (1.7%) | 12/34 (3.3%) | 30.99 (4.15 to 1387.39) | <0.0001 | 0/43 (0%) | 6/19 (31.6%) | Inf (3.27 to Inf) | 0.0004 |
| Multiple organ failure | 25/60 (41.7%) | 29/34 (85.3%) | 7.93 (2.56 to 29.96) | <0.0001 | 18/43 (41.9%) | 15/19 (78.9%) | 5.07 (1.32 to 24.56) | 0.012 |
| Sepsis | 4/60 (6.7%) | 12/34 (35.3%) | 7.45 (1.99 to 35.14) | 0.001 | 2/43 (4.7%) | 7/19 (36.8%) | 11.37 (1.85 to 126.32) | 0.0024 |
| Venous thrombosis | 5/60 (8.3%) | 7/34 (20.6%) | 2.82 (0.7 to 12.38) | 0.1117 | 2/43 (4.7%) | 5/19 (26.3%) | 7.04 (1.02 to 81.66) | 0.0238 |
| Peripheral pulmonary embolism | 3/60 (5%) | 1/34 (2.9%) | 0.58 (0.01 to 7.55) | 1 | 2/43 (4.7%) | 1/19 (5.3%) | 1.14 (0.02 to 23.16) | 1 |
| Hemofiltration | 1/60 (1.7%) | 12/34 (3.3%) | 30.99 (4.15 to 1387.39) | <0.0001 | 0/43 (0%) | 6/19 (31.6%) | Inf (3.27 to Inf) | 0.0004 |
| Ventilator-free days | 25 (17.75–27) | 13.5 (0.5–21) | 9 (4–13) | <0.0001 | 24 (14–26.5) | 16 (7–22.5) | 5 (0–11) | 0.0552 |
| ICU-free days | 22 (14.75–25) | 6.5 (0–18.5) | 9 (4 to 15) | 0.0003 | 19 (8–24) | 16 (3.5–24) | 2 (−3 to 8) | 0.4263 |
| Hospital-free days | 2 (0–12) | 0 (0–4.75) | 0 (0–3) | 0.0298 | 2 (0–9.5) | 0 (0–8) | 0 (0 to 3) | 0.2295 |
| In-hospital mortality | 0/60 (0%) | 7/34 (20.6%) | Inf (2.9 to Inf) | 0.0005 | 0/43 (0%) | 3/19 (15.8%) | Inf (0.99 to Inf) | 0.0256 |
Inf, infinitive means >4 at sofa score. mathematical correct is infinitive if it is >4. Binary data are presented as no./total no. (%) and continuous data as medians (IQR). Estimates are odds ratios for binary variables and estimated median differences for continuous variables. Differences between patients without and with platelet transfusion assessed by Fisher’s Exact Test for binary variables and Wilcoxon Rank Sum Test for continuous variables. PC, Platelet Concentrate; SOFA, Sequential Organ Failure Assessment Score.