Table 1.

Most frequent causes of liver steatosis.

Metabolic: Nonalcoholic fatty liver (NAFLD) or metabolic-dysfunction-associated fatty liver disease (MAFLD)

Alcoholic liver disease (ALD)

Hepatitis C (in particular genotype 3)

Lipodystrophy

Parenteral nutrition

Starvation

Wilson disease

Abetalipoproteinemia

Drugs (e.g., methotrexate, tamoxifen, glucocorticoids, amiodarone, valproate, anti-retroviral agents for HIV)

Acute fatty liver of pregnancy

HELLP (hemolytic anemia, elevated liver enzymes, low platelet count) syndrome

Reye syndrome

Inborn errors of metabolism (LCAT deficiency, cholesterol ester storage disease, Wolman disease)

Drug-induced liver disease

Food contaminants of environmental origin (e.g., endocrine disrupting chemicals, persistent organic pollutants, metals)