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Displacement of NEIL1 by DNA polymerase β. (A) POLβ interacting with NEIL1 bound to the downstream strand; (B) POLβ interacting with NEIL1 bound to the template strand. White circles show the secondary substrate cleavage in the absence of POLβ, black circles, in the presence of POLβ and dNTPs and black triangles, in the presence of POLβ without dNTPs. Mean ± SEM of 3–4 independent experiments are presented.
