Table 1.

KRAS, LKB1 and KEAP1 mutational status and KRAS copy number variation (CNV) of the NSCLC cells used, obtained by the COSMIC database [16]. Overexp: overexpression without a clear gene duplication, red: CB-839 resistant cell lines, green: CB-839 sensitive cell lines.

CELL LINE	KRAS	KRAS CNV	LKB1	KEAP1
H1792	G12C	NO	WT	LOSS
H1975	WT	-	WT	WT
H358	G12C	OVEREXP	WT	WT
H2030	G12C	NO	LOSS	LOSS
H520	WT	-	WT	WT
H358_7	G12C	-	LOSS	WT
H23	G12C	OVEREXP	LOSS	LOSS
H1650	WT	-	WT	WT
H460	Q61H	NO	LOSS	LOSS
A549	G12S	NO	LOSS	LOSS
LU99	G12C	5	WT	WT
LU99_2	G12C	-	LOSS	WT