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A: Structures of CasC1, CasC3, CasC4 with the photo-activable crosslinker R at the N-terminus; B: structures of CasC2, CasC5, CasC6 with the photo-activable crosslinker R at the C-terminus; C: Structures of backbone modification (red box, either Ψ[Tz] or Ψ[CH2NH]) at Asp4-Ala5 and of the photo-cleavable linkers.
