Table 2.

Treatment-related adverse events.

Adverse Event	Overall, n (%)	Grade 1, n (%)	Grade 2, n (%)	Grade 3, n (%)
Total	26	18	4	4
Laboratory abnormalities
Increased ALT/AST	4 (16)	3 (17)	0 (0)	1 (25)
Increased alkaline phosphatase	3 (12)	3 (17)	0 (0)	0 (0)
Increased bilirubin	1 (4)	0	1 (25)	0
Increased creatinine	1 (4)	0	1 (25)	0
Anemia	5 (19)	2 (11)	1 (25)	2 (50)
General disorders
Anorexia	1 (4)	1 (6)	0	0
Dysgeusia	1 (4)	0	1 (25)	0
Fatigue	3 (12)	3 (17)	0	0
Genital edema	1 (4)	1 (6)	0	0
Limb edema	2 (8)	2 (11)	0	0
Hyperthyroidism	1 (4)	1 (6)	0	0
Neurological disorders
Peripheral sensory neuropathy	1 (4)	1 (6)	0	0
III cranial nerve paralysis	1 (4)	0	0	1 (25)
Rash macula-papular	1 (4)	1 (6)	0	0

ALT/AST, alanine aminotransferase/aspartate aminotransferase.