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. 2020 Aug 14;9(8):1901. doi: 10.3390/cells9081901

Table 1.

Adapted from [9] showing incorporation of molecular risk factors and median overall survival (OS) for respective risk groups; Int, Intermediate.

Scoring System Criteria Low Risk Int Risk High Risk
MIPSS-PV Age > 67 years (2 points)
Leukocyte count ≥15 × 109/L (1 point)
Adverse Mutation—SRSF2 (3 points)
Thrombosis history (1 point)
0–1 point
Median OS
24 years
2–3 points
Median OS
13.1 years
≥4 points
Median OS
3.2 years
MIPSS-ET Age > 60 years (4 points)
Male gender (1 point)
Leukocyte count ≥11 × 109/L (1 point)
Adverse Mutations—SRSF2, SF3B1, U2AF1, TP53 (2 points)
0–1 point
Median OS
34.4 years
2–5 points
Median OS
14.1 years
≥6 points
Median OS
7.9 years