Table 1.
Summary of the effect of WT, S47A, and S47E Cytc on different mitochondrial functions involving Cytc.
| Cytc Function | WT | S47A | S47E/S47D | EV | Reference |
|---|---|---|---|---|---|
| Brain cytochrome c oxidase (COX) activity | 100% | ~82% | ~46% | - | [12] |
| Caspase-3 activity | 100% | ~38% | ~35% | - | [12] |
| 100% | ~50% | ~30% | [53] | ||
| Cardiolipin peroxidase activity (cardiolipin: Cytc) | 100% (10:1) | ~37% (10:1) | ~50% (10:1) | - | [12] |
| 100% (20:1) | ~54% (20:1) | ~51% (20:1) | |||
| 100% (100:1) | ~60% (100:1) | ~80% (100:1) | [53] | ||
| Intact cell respiration | 100% | ~81% | ~42% | ~15% | This study |
| Mitochondrial membrane potential | 100% | ~93% | ~79% | ~55% | This study |
| Mitochondrial ROS production | 100% | ~74% | ~70% | ~63% | This study |
| ATP production | 100% | ~100% | ~84% | ~28% | This study |
| Cell death (after OGD/R) | ~32% | ~30% | ~18% | - | This study |
| Cell death (after H2O2 treatment) | ~25% | ~13% | ~11% | - | This study |