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. 2020 Aug 18;10(8):1199. doi: 10.3390/biom10081199

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Changes in the signaling network of colorectal cancer (CRC) liver metastases upon decorin delivery. Liver-specific transfection with the DCN gene inhibited several RTKs with a concomitant decrease in the activity of the MAPK/ERK and Akt/mTOR/p70S6K pathways. Increased AMPK (possibly via LKB1) and p38/MSK/CREB signaling resulted in elevated phospho-p53 levels; stabilization of this key tumor suppressor may result in a cell cycle blockade. Inhibition of STATs and c-Jun proteins also contributes to the antitumor action of decorin. Color code: red: decreased; green: increased; orange: no change; grey: not examined. Additional details are included in the text.