Table 1.

Changes in signaling proteins detected by phosphokinase array. The table shows the relative protein levels in decorin-transfected (DCN) versus null-vector-transfected mice inoculated with c38 colorectal cancer cells. Data represent the mean of two independent experiments.

Protein	Phosphorylation Site	Relative Level in DCN Group (%)	p Value
Akt 1/2/3 (S473)	S473	139.277	0.085
Akt 1/2/3 (T308)	T308	96.147	0.083
AMPKα1 (T183)	T183	107.259	0.027
AMPKα2 (T172)	T172	109.825	0.124
Chk-2	T68	105.490	0.517
c-Jun	S63	80.634	0.016
CREB	S133	114.239	0.103
EGF R	Y1086	97.511	0.274
eNOS	S1177	96.573	0.528
ERK1/2	T202/Y204, T185/Y187	79.370	0.045
FAK	Y397	87.540	0.343
Fgr	Y412	73.382	0.047
Fyn	Y420	99.185	0.220
GSK-3α/β	S21/S9	98.895	0.126
Hck	Y411	103.026	0.210
HSP27	S78/S82	85.398	0.014
HSP60	-	107.067	0.042
JNK 1/2/3	T183/Y185, T221/Y223	114.402	0.438
Lck	Y394	100.697	0.567
Lyn	Y397	109.082	0.371
MSK1/2	S376/S360	117.438	0.038
p27	T198	106.962	0.336
p38α	T180/Y182	108.060	0.435
p53 (S46)	S46	104.783	0.276
p53 (S15)	S15	112.702	0.185
p53 (S392)	S392	117.981	0.064
p70 S6 Kinase	T421/S424	79.221	0.050
p70 S6 Kinase (T389)	T389	78.876	0.059
PDGF Rβ	Y751	70.647	0.012
PLC-γ1	Y783	75.498	0.026
PRAS40	T246	116.635	0.067
PYK2	Y402	79.806	0.083
RSK1/2/3	S380/S386/S377	90.656	0.072
Src	Y419	110.985	0.089
STAT2	Y689	87.833	0.139
STAT3	Y705	84.852	0.117
STAT3	S727	96.977	0.462
STAT5a	Y694	85.820	0.157
STAT5a/b	Y694/Y699	82.277	0.287
STAT5b	Y699	75.547	0.016
STAT6	Y641	92.892	0.083
TOR	S2448	97.492	0.346
WNK1	T60	82.123	0.053
Yes	Y426	97.223	0.313
β-Catenin	-	84.948	0.025