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. 2020 Aug 5;9(8):2526. doi: 10.3390/jcm9082526

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Purified A1AT reduces SERPINA1 expression in a dose-dependent manner in primary human hepatocytes. Exogenously added purified AAT reduced SERPINA1 expression in primary human hepatocytes isolated from both proficient and deficient liver tissue. The reduction was more prominent following Oncostatin M (OSM 10 ng/mL) stimulation, known to increase expression of SERPINA1. *, P < 0.05; **, P < 0.001; ***, P < 0.001; ****, P < 0.0001). © 2017 Karadagi, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Obtained from Reference [44].