Figure 6.

Effect of the treatment of fisetin, 5-FU or their combination on tumor growth (late) in FC¹3K¹Apc^Min/+ mice. Treatment with fisetin and 5-FU seemed to extend the life of experimental animals. To determine whether the drugs were effective on tumors that were more advanced, a second set of experimental mice received drugs starting between 45 and 53 days of age. Mice were given up to five rounds of treatment and euthanized when moribund or when the study was completed. Tumor growth was monitored by colonoscopy and plotted. [Color figure can be viewed at wileyonlinelibrary.com]