Table 2.
Longitudinal change of cortical thickness in the white matter hyperintensity (WMH) progression group compared with the WMH regression group.
| All svMCI (n = 87) | PiB Negative svMCI (n = 51) | |||
|---|---|---|---|---|
| B (SE) | p-Value | B (SE) | p-Value | |
| Global thickness | −0.034 (0.012) | 0.006 | −0.027 (0.012) | 0.030 |
| Frontal lobe | −0.041 (0.013) | 0.002 | −0.028 (0.013) | 0.033 |
| Temporal lobe | −0.040 (0.016) | 0.014 | −0.035 (0.015) | 0.024 |
| Parietal lobe | −0.034 (0.012) | 0.005 | −0.032 (0.012) | 0.009 |
| Occipital lobe | −0.025 (0.011) | 0.029 | −0.019 (0.014) | 0.173 |
Abbreviations: WMH— white matter hyperintensity; SE—standard error. A linear mixed effects model was performed after adjusting for baseline age, sex, time, group, intracranial volume, Pittsburgh compound B standardised uptake value ratio, and the interaction between the groups and time.