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. 2020 Aug 2;12(8):2142. doi: 10.3390/cancers12082142

Figure 6.

Figure 6

Relationship between EBV proteins and c-MYC and the modes of action of compounds with lytic induction potentials. MYC represses the activation of lytic cycle of EBV by binding to OriLyt on the EBV genome and suppresses its looping to the BZLF1 promoter. A2CE’s and DRB’s inhibition of CDK2/9, a transcription factor that regulates MYC expression, can suppress the expression of EBV latent proteins. Compounds that target the DNA binding domain of the MYC-MAX complex such as KSI-3716, MYCi975, and 7594-0035 may reactivate the lytic cycle of EBV.