Figure 3.

The associations of LVI status and lymphangiogenesis, as well as extracellular matrix (ECM) degradation in PDACs. (A) Gene expression comparison involved in lymphangiogenesis between the LVI-negative and positive tumors. (B) Gene expression comparison involved in angiogenesis between the LVI-positive and negative tumors. (C) Gene set enrichment analysis (GSEA) of the angiogenesis gene set, comparing the LVI-positive and negative tumors. (D) Gene expression comparison involved in ECM degradation between the LVI-positive and negative tumors. PDPN = podoplanin; NRP2 = neuropilin-2; VEGF = vascular endothelial growth factor; ANGTP = Angiopoietins; HIF = hypoxia-inducible factor; PDGF = platelet-derived growth factor; FGF = fibroblast growth factor; LYVE = lymphatic vessel endothelial hyaluronan receptor; PROX = prospero homeobox protein; ES = enrichment score; NES = normalized enrichment score; MMP = matrix metalloproteinase.