Table 2.
Univariate/multivariate analyses (COX proportional hazards model) for OS.
| Univariate Analysis | Multivariate Analysis | |||||
|---|---|---|---|---|---|---|
| Variables | p Value | Hazard Ratio | 95% CI | p Value | Hazard Ratio | 95% CI |
| Age (≥ 65) | 0.750 | 1.053 | 0.763–1.451 | |||
| Sex (M) | 0.875 | 0.975 | 0.709–1.344 | |||
| Tumor size (≥ 3.5 cm) | 0.530 | 0.898 | 0.641–1.256 | |||
| AJCC T (T3 + T4) | 0.717 | 0.983 | 0.430–1.635 | |||
| AJCC N (N1) | 0.08 | 1.556 | 0.950–2.691 | |||
| Histologic grade (G3) | 0.124 | 1.412 | 0.909–2.192 | |||
| Residual tumor status (R1 + R2) | 0.021 | 1.703 | 1.084–2.677 | 0.125 | 1.580 | 0.881–2.834 |
| Adjuvant radiation (Yes) | 0.002 | 0.403 | 0.200–0.736 | 0.017 | 0.325 | 0.129–0.817 |
| Perineural invasion (PNI +) | 0.282 | 1.472 | 0.747–3.342 | |||
| Lymphovascular invasion (LVI +) | 0.011 | 1.883 | 1.150–3.216 | 0.012 | 2.401 | 1.218–4.759 |