Table 2.

Associations between genomic and transcriptomic features and clinicopathological characteristics.

Clinicopathological Characteristics	Genomic Instability	Photoreceptor Gene Signature
		High	Low
Laterality [33,45]	Unilateral	Bilateral	Unilateral
Tumor grade * [33,44,45]	Less differentiation	Differentiation	Less differentiation
Age at diagnosis/enucleation [33,45,51,52]	Older	Younger	Older
High-risk features (optic nerve/choroid invasion) [33,44,45]	Not associated	Not associated	Not associated
Tumor volume [33,45]	Not associated	Smaller	Larger
Tumor location [45,53]	N/a	Central retina	Peripheral retina/entire retina
Eye size [53]	N/a	Smaller	Larger
Number of lesions [33,53]	Not associated	1–5 lesions	>5 lesions
Chemotherapy sensitivity [45]	N/a	Less sensitivity	More sensitivity

N/a: not available; * Presence/absence of Flexner–Wintersteiner rosettes.