Figure 2.

Effects of adipocytokines from the pericardial and peripheral fat tissues of the study groups on the delayed-rectifier potassium current (I_K) in H9c2 cells. (A) Representative recordings of I_K elicited by 300 ms of depolarizing step pulses from −70 to 50 mV at a holding potential of −60 mV in H9c2 cells treated with adipocytokines from the pericardial fat of different groups for 18 h. (B) Average relationship between the I_K (pA/pF) and membrane potential in H9c2 cells treated with adipocytokines from the pericardial fat in the control, metabolic syndrome (MS), empagliflozin (EMPA), and glibenclamide (GLI) groups (n = 10). (C) Representative recordings of the I_K elicited by 300 ms of depolarizing step pulses from −70 to 50 mV at a holding potential of −60 mV in H9c2 cells treated with adipocytokines from the pericardial fat of different groups for 18 h. (D) Average relationship between the I_K (pA/pF) and membrane potential in H9c2 cells treated with adipocytokines from the peripheral fat in the control, MS, EMPA, and GLI groups (n = 10). * p < 0.05 compared with the control; # p < 0.05 compared with the EMPA; △p < 0.05 compared with the GLI. MS: metabolic syndrome; EMPA: empagliflozin; GLI: glibenclamide.