Table 2.
The top 5 BP, CC, and MF enrichment analyses of the upregulated and downregulated DEGs
| Ontology | ID | Description | Gene ratio | P value | P adjust | Gene ID | Count |
|---|---|---|---|---|---|---|---|
| BP | GO:0001501 | Skeletal system development | 12/81 | 1.55E−06 | 0.003 | COL1A2/PAPSS1/GJA1/COL3A1/TIMP1/LUM/CTSK/MGP/PPIB/PLS3/SPARC/TGFBI | 12 |
| BP | GO:0042176 | Regulation of protein catabolic process | 10/81 | 4.33E−06 | 0.004 | GSK3A/MSN/EEF1A1/GJA1/GPX1/TIMP1/CLU/NDUFA13/CDK5RAP3/PTTG1IP | 10 |
| BP | GO:0030198 | Extracellular matrix organization | 9/81 | 1.96E−05 | 0.013 | COL1A2/COL3A1/TIMP1/LUM/COL5A2/CTSK/FN1/HTRA1/SPARC | 9 |
| BP | GO:0030199 | Collagen fibril organization | 4/81 | 5.02E−05 | 0.021 | COL1A2/COL3A1/LUM/COL5A2 | 4 |
| BP | GO:0043062 | Extracellular structure organization | 9/81 | 6.18E−05 | 0.021 | COL1A2/COL3A1/TIMP1/LUM/COL5A2/CTSK/FN1/HTRA1/SPARC | 9 |
| BP | GO:0030168 | Platelet activation | 6/81 | 6.50E−05 | 0.021 | ACTB/COL1A2/NOS3/COL3A1/ACTG1/CLIC1 | 6 |
| CC | GO:0062023 | Collagen-containing extracellular matrix | 17/84 | 1.98E−12 | 5.40E−10 | COL1A2/PCOLCE/ASPN/LGALS1/COL3A1/TIMP1/THBS2/LUM/COL5A2/MGP/MXRA5/S100A4/FN1/CLU/HTRA1/SPARC/TGFBI | 17 |
| CC | GO:0031012 | Extracellular matrix | 17/84 | 2.47E−11 | 3.37E−09 | COL1A2/PCOLCE/ASPN/LGALS1/COL3A1/TIMP1/THBS2/LUM/COL5A2/MGP/MXRA5/S100A4/FN1/CLU/HTRA1/SPARC/TGFBI | 17 |
| CC | GO:0005583 | Fibrillar collagen trimer | 4/84 | 1.23E−07 | 8.37E−06 | COL1A2/COL3A1/LUM/COL5A2 | 4 |
| CC | GO:0098643 | Banded collagen fibril | 4/84 | 1.23E−07 | 8.37E−06 | COL1A2/COL3A1/LUM/COL5A2 | 4 |
| CC | GO:0098644 | Complex of collagen trimers | 4/84 | 1.11E−06 | 6.06E−05 | COL1A2/COL3A1/LUM/COL5A2 | 4 |
| MF | GO:0005201 | Extracellular matrix structural constituent | 12/80 | 9.73E−12 | 2.35E−09 | COL1A2/PCOLCE/ASPN/COL3A1/THBS2/LUM/COL5A2/MGP/MXRA5/FN1/SPARC/TGFBI | 12 |
| MF | GO:0005518 | Collagen binding | 8/80 | 4.10E−10 | 4.97E−08 | PCOLCE/ASPN/LUM/CTSK/PPIB/FN1/SPARC/TGFBI | 8 |
| MF | GO:0097718 | Disordered domain-specific binding | 3/80 | 0.000412372 | 0.033 | GJA1/FN1/GAPDH | 3 |
| MF | GO:0030020 | Extracellular matrix structural constituent conferring tensile strength | 3/80 | 0.000945361 | 0.037 | COL1A2/COL3A1/COL5A2 | 3 |
| MF | GO:0099186 | Structural constituent of post-synapse | 2/80 | 0.000963809 | 0.037 | ACTB/ACTG1 | 2 |
| KEGG | hsa05205 | Proteoglycans in cancer | 8/50 | 3.50E−05 | 0.004 | ACTB/COL1A2/MSN/CD63/LUM/FN1/ACTG1/RPS6 | 8 |
| KEGG | hsa04611 | Platelet activation | 5/50 | 0.001031369 | 0.059 | ACTB/COL1A2/NOS3/COL3A1/ACTG1 | 5 |
| KEGG | hsa04151 | PI3K-Akt signaling pathway | 8/50 | 0.001491165 | 0.059 | YWHAB/COL1A2/SGK1/NOS3/THBS2/FN1/RPS6/CHRM1 | 8 |
| KEGG | hsa04810 | Regulation of actin cytoskeleton | 6/50 | 0.00205303 | 0.061 | ACTB/MSN/PFN2/FN1/ACTG1/CHRM1 | 6 |
| KEGG | hsa04714 | Thermogenesis | 6/50 | 0.003083363 | 0.069 | ACTB/ACTG1/NDUFA13/RPS6/ND2/UQCRH | 6 |