Table 2.
Patents related to ATRA delivery systems in cancer.
| Novelty | Number of the Patent | Priority Date | Publication Date | National | International |
|---|---|---|---|---|---|
| Nano-fibular nanoparticles polymer-ATRA conjugate for sustained dermal delivery | WO2016210087A1; US2018185513A1 | 23rd June 2015 | 29th December 2016 (WO2016210087A1); 5th July 2018 (US2018185513A1) | USA | PCT |
| ATRA-loaded liposomal aerosols for delivery to the lungs | US6334999B1 | 27th August 1999 | 1st January 2002 | USA | - |
| ATRA/TGFβ-loaded (PLGA) polymeric nanoparticles for the treatment of Type 1 Diabetes Mellitus | WO2015109245A1; US2016338984A1; US10105334B2 | 17th January 2014 | 23rd July 2015 (WO2015109245A1); 24th November 2016 (US2016338984A1); 23rd October 2018 (US10105334B2) | USA | PCT |
| ATRA quasicrystal-loaded liposomes for the treatment of solid tumors | CN109364027A | 12nd December 2018 | 22nd February 2019 | China | - |
| ATRA-loaded liposomes for the treatment of solid tumors | WO2018033118A1; CN107753427A; EP3501500A1 | 18th August 2016 | 22nd February 2018 (WO2018033118A1); 6th March 2018 (CN107753427A); 26th June 2019 (EP3501500A1) | China | PCT; European patent |
| ATRA/aPD-L1-loaded (PLGA-PEG) polymeric nanoparticles for the treatment of oral dysplasia and oral squamous carcinoma | CN110623942A | 30th September 2019 | 31st December 2019 | China | - |