Table 1.
Demography of human benign and malignant tissue samples from Ontario Tumor Bank: this table illustrates tobacco exposures, alcohol consumption, hormone receptor status (ER, PR, HER2), and tumor stage status of the benign and malignant human tissue samples used in this study. Samples were age-matched; the majority of samples are from female patients, only three samples are male. Hormone receptor status of weak and intermediate was considered neither negative nor positive. Age and pack year were presented as mean ± SD.
| Subjects | Benign N = 20 (%) |
Malignant N = 96 (%) |
|
|---|---|---|---|
| Sex | Female | 20 (100) | 93 (96.88) |
| Male | 0 (0) | 3 (3.13) | |
| Age Distribution (Years) |
Range | 52–87 | 27–92 |
| Age (years) | Mean ± SD | 66 ± 11 | 63 ± 17 |
| Smoking | Smokers | 1 (5) | 24 (25) |
| Pack Year (PY) ± SD |
40 | 27 ± 19 | |
| Alcohol Consumption |
Social or Occasional Drinker | 5 (25) | 28 (29.17) |
| Regular Drinker | 0 (0) | 3 (3.13) | |
| ER Status | Positive | N/A | 37 (38.58) |
| Negative | N/A | 19 (19.79) | |
| Unknown | N/A | 6 (6.25) | |
| PR Status | Positive | N/A | 31 (32.29) |
| Negative | N/A | 30 (31.25) | |
| Unknown | N/A | 6 (6.25) | |
| HER2 Status | Positive | N/A | 21 (21.88) |
| Negative | N/A | 61 (63.54) | |
| Unknown | N/A | 14 (14.58) | |
| ER, PR, HER2 Status | Negative | N/A | 10 (10.42) |
| Tumor Stage | |||
| I * | N/A | 7 (7.29) | |
| II | N/A | 45 (46.87) | |
| III | N/A | 39 (40.63) | |
| IV | N/A | 5 (5.21) | |
N/A: Not Applicable. * Stage 0 samples (n = 2) were compiled with stage I samples and considered as stage I (n = 5).