Table 1.

Protein substrates of GRP94.

Protein Substrate	Refs	Major Expression	Notable Structural Features
Immunoglobulin L chain H chain	[50,51]	B lineage cells	Immunoglobulin fold Non-glycosylated secreted Glycosylated secreted or membrane-spanning
Toll-like receptor	[52,53]	Ubiquitous, predominantly leukocytes	Leucine-rich repeats; Membrane-spanning proteins
Integrins	[48]	Ubiquitous	Immunoglobulin superfamily membrane-spanning heterodimers
LRP6	[54,55]		EGF-like repeats β-propeller motifs Interacts indirectly via MesD
Glycoprotein Ib-IX-V complex	[56]	Platelets
Insulin-like proteins IGF-I IGF-II Insulin	[38,57,58]	Ubiquitous Pancreatic β cells
Thyroglobulin	[59,60]	Thyrocytes	Large disulfide-bonded protease-type repeats
GARP	[61]	Treg cells; Platelets	Membrane-spanning leucine-rich repeats domains Tregs and platelets