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. 2020 Aug 9;9(8):1866. doi: 10.3390/cells9081866

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The HP1a and HIPP1 proteins co-localize at homeotic genes along with the AP. The HP1a and HIPP1 proteins co-localize at the Fub insulator (the first violet box) in the Abd-a gene along with CP190, Su (Hw), CTCF, and Mod (mdg4), and Ibf 1 and 2. From the previously published ChIP data on S2 cells, we find HP1a (dark red), HIPP1 (pink), and some architecture proteins (purple). The adjacent insulators Mcp and Fab8 do not co-localize with HP1a (center and right violet boxes). The regions with insulators are marked with dotted arrows inside a violet shadow. At the bottom are the Abd-a and Abd-b genes and their locations; the reference in kilobases.