Table 5.
Multivariate analysis of microRNAs and pathological characteristics in CRC with the high lymphatic invasion.
| Prognostic factors | p-Value | Odds Ratio | 95% Confidence Interval |
|---|---|---|---|
| Pathological T stage § (T3+T4/T1+T2) |
0.66 | 1.84 | 0.12–33.45 |
| Venous invasion ¶ (high/mild) |
<0.001 *** | 66.84 | 5.10–2853.98 |
| Perineural invasion ¶ (positive/negative) |
0.53 | 0.46 | 0.03–5.70 |
| Level of MIR92a in tumor tissue (−∆Ct value‡) (high/low) |
0.01 * | 0.08 | 0.003–0.60 |
| Level of MIR21 in preoperative plasma (−∆Ct value ‡) (high/low) |
0.19 | 0.20 | 0.008–2.16 |
| Level of MIR29a in preoperative plasma (−∆Ct value ‡) (high/low) |
0.009 ** | 30.72 | 2.24–1038.11 |
‡: −∆Ct value = −(Ct value (target MIR)–Ct value (internal control MIR16)), §: UICC TNM classification (the 8th edition), ¶: the Japanese Classification of Colorectal, Appendiceal, and Anal Carcinoma: the 3rd English Edition (*: p < 0.05 **: p < 0.01 ***: p < 0.001).