Table 1.
Demographic and biological characteristics of the study population.
| Characteristics | Whole Population | B12 Deficiency | No B12 Deficiency |
|---|---|---|---|
| (n = 127) | (n = 69) | (n = 58) | |
| General characteristics | |||
| Age (years) | 66 (44–81) | 74 (55–83) | 60 (39–73) |
| Gender (female) | 77 (60.6%) | 48 (69.6%) | 29 (50%) |
| BMI (kg/m²) | 25.1 (22.3–28.5) | 25.5 (22.4–29.0) | 24.7 (22.4–28.0) |
| Tobacco misuse | 36 (28.3%) | 17 (24.6%) | 19 (32.8%) |
| Alcohol misuse | 8 (6.3%) | 6 (8.7%) | 2 (3.4%) |
| Biochemical Profiles | |||
| eGFR MDRD (mL/min/1.73 m2) | 99.5 (70.1–123.7) | 88.1 (52.9–113.2) | 105.3 (81.2–127.0) |
| Plasma B12 (ng/L) | 291 (260–314) | 291 (261–315) | 290 (260–310) |
| Plasma Folate (µg/L) | 5.6 (3.7–7.4) | 4.7 (3.5–7.0) | 5.85 (4.20–7.93) |
| Plasma MMA (mmol/L) | 0.32 (0.22–0.54) | 0.53 (0.38–0.71) | 0.23 (0.18–0.28) |
| Plasma HCyst (µmol/L) | 14.7 (10.7–19.3) | 19.1 (14.4–22.5) | 11.2 (9.4–14.2) |
| Urinary MMA (µmol/L) | 8.3 (0.0–14.9) | 10.1 (0.0–15.2) | 5.9 (0.0–13.9) |
| Urinary Creatinine (mmol/L) | 6.5 (3.9–10.2) | 6.1 (3.9–8.3) | 7.8 (4.2–12.1) |
| uMMA/C ratio (µmol/mmol) | 1.1 (0.0–1.8) | 1.6 (0.0–2.2) | 0.7 (0.0–1.2) |
Qualitative data expressed as absolute values and percentages. Quantitative data expressed as medians and quartiles. BMI = Body Mass Index; eGFR = estimated Glomerular Filtration Rate; MDRD = Modification of Diet in Renal Disease; MMA = Methylmalonic Acid; HCyst = Homocysteine; uMMA/C = urinary Methylmalonic Acid to Creatinine ratio.