Figure 2.

The inhibitory activity of sevanol (s706) and its analogues. Currents were elicited by a drop from pH 7.4 to 5.5; the holding potential was −50 mV; (A,C) are dose–response curves for s706, s590 and EA inhibitory effects on ASIC1a and ASIC3 channels, respectively; (B,D) are reciprocal IC₅₀ values for s706, s590 and EA inhibitory effects on ASIC1a and ASIC3 channels, respectively. The data were fitted by the logistic equation. Each point is the mean ± SEM of 5–6 measurements. * p < 0.05, ** p < 0.005.