Figure 5.

The analgesic and anti-inflammatory effects of sevanol following intravenous, intranasal and per os administration. The effect of sevanol on the acetic acid induced writhing (A–C) and on the mice withdrawal latency on a hot plate in the thermal hyperalgesia test after CFA injection (D–F) upon intravenous (A,D), intranasal (B,E) and oral (C,F) administration. Pretreating the mice with sevanol (30 min before testing) attenuated the response to the intraperitoneal administration of acetic acid, as estimated by the number of writhes in 30 min intervals, and significantly reversed CFA-induced thermal hyperalgesia prolonging the withdrawal latency for an inflamed hind paw placed on a hot plate. The results are presented as the mean ± SD (n = 6–10). The p-values of the sevanol groups vs. the saline group are based on an analysis of variance and on Tukey’s test; * p < 0.05, ** p < 0.005, *** p < 0.001.