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. 2020 Jul 27;9(8):671. doi: 10.3390/antiox9080671

Figure 1.

Figure 1

Increased oxidatively-damaged proteins accumulation in the cerebral cortex of Biliverdin reductase-A (BVR-A−/−) mice. Slot Blot quantification of 4-hydroxy-2-nonenal (HNE) (A.1,A.2) and 3-NT levels (B.1,B.2) evaluated in the cerebral cortex of wild-type (WT) and BVR-A−/− mice at 2 (n = 4), 6 (n = 4) and 11 (n = 4) months of age. Data are expressed as percentage of WT mice at 2 months set as 100%. Columns were used to show differences among the groups (WT vs. BVR-A−/−) while dots to show age-associated changes within each group. Data are expressed as Mean ± SEM. For columns: * p < 0.05, ** p < 0.01 vs. WT (2-way ANOVA with Fisher’s LSD test). For dots: # p < 0.05, ## p < 0.01, ### p < 0.001 vs. 2 months; + p < 0.05, ++ p < 0.01 vs. 6 months (2-way ANOVA with Fisher’s LSD test).