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. 2020 Jul 27;9(8):671. doi: 10.3390/antiox9080671

Figure 2.

Figure 2

mTOR hyper-activation occurs in the cerebral cortex of BVR-A−/− mice. Representative western blot images (A) and densitometric evaluation of mTOR (B.1,B.2), p-mTORSer2448 (C.1,C.2) and p-mTORSer2448/mTOR ratio (D.1,D.2) in the cerebral cortex of WT and BVR-A−/− mice at 2 (n = 4), 6 (n = 4) and 11 (n = 4) months of age. Protein levels were normalized per total protein load. Data are expressed as percentage of WT mice at 2 months set as 100%. Columns were used to show differences among the groups (WT vs. BVR-A−/−) while dots to show age-associated changes within each group. Data are expressed as Mean ± SEM. For columns: * p < 0.05, *** p < 0.001 vs. WT (2-way ANOVA with Fisher’s LSD test). For dots: # p < 0.05, ## p < 0.01, ### p< 0.001 vs. 2 months; ++ p < 0.01, +++ p < 0.001 vs. 6 months (2-way ANOVA with Fisher’s LSD test).