Figure 3.

Schematic representation of tRNA modifications affected by nutritional and environmental stressors. The description of these factors, their associated modifications along with references are also noted in Table S1. Modifications affected by more than one condition are indicated with corresponding colored rings. *2-O’-methyladenosine (Am32) and 2-O’-methyluridine (Um32) are additionally affected by oxidative stress. The numbers “1” and “9” found within each base denote the β-glycosidic bond orientation found in the pyrimidine and purine bases, with their adjacent riboses in tRNA. The structure of the full nucleoside is only shown for modifications containing 2′-O-methylation.