Table 2.

Cox regression model analysis for risk factors of postoperative tumor recurrence in 362 patients with esophageal cancer undergoing esophagectomy and reconstruction with gastric pull-up and cervical esophagogastrostomy. Abbreviations: HR: hazard ratio, SE: standard error, CI: confidence interval, BMI: Body Mass Index, ASA: ASA-Physical status (American Society of Anaesthesiologists), CRP: preoperative C-reactive protein, RFS: relapse free survival. Cox’ proportional hazards model was used as a statistical test, in both univariate and multivariate (stepwise forward) analysis. The 11 variables which were significant in the univariate analysis were entered together into the multivariate (stepwise forward) analysis, where only four of them remained in the final model.

Characteristic	HR	SE	95% CI	p Value
RFS
Univariate Analysis
Age	0.999	0.006	0.986–1.013	0.968
Gender	1.302	0.295	0.834–2.030	0.244
BMI	0.980	0.016	0.947–1.013	0.247
ASA	1.259	0.134	1.002–1.551	0.030
CRP	1.010	0.002	1.004–1.015	<0.001
Albumin	0.689	0.100	0.518–0.916	0.011
Histology	1.874	0.275	1.405–2.499	<0.001
Tumor location	0.594	0.063	0.482–0.733	<0.001
Tumor differentiation	1.705	0.219	1.324–2.194	<0.001
Tumor infiltration	1.675	0.134	1.432–1.960	<0.001
Lymph node involvement	1.763	0.125	1.533–2.027	<0.001
Tumor stage	1.580	0.097	1.400–1.784	<0.001
Resection margin	2.312	0.370	1.688–3.166	<0.001
Neo-adjuvant treatment	1.341	0.207	0.990–1.817	0.057
Adjuvant treatment	1.653	0.284	1.181–2.314	0.003
Multivariate Analysis
Histology	1.956	0.315	1.426–2.683	<0.001
Tumor stage	1.592	0.110	1.389–1.824	<0.001
Tumor differentiation	1.426	0.200	1.082–1.879	0.012
Resection margin	1.635	0.277	1.782–2.280	0.004