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Hypothesis of mode of actions of memantine for its NMDA receptor antagonist activity.
| Mode of Actions | Main References |
|---|---|
| Low affinity/fast off-rate | [45,50,51,53] |
| Voltage dependency/fast unblocking kinetics | [50,51,52,53,54,55] |
| Partial trapping | [54,55,56] |
| Uncompetitive antagonism/ agonist concentration dependency |
[53,57,58,59,60] |
| Preferential inhibition of extrasynaptic receptors | [65,66,67,68,69,70] |
