Table 1.
Role of ROS-induced ROS release in angiogenesis and vascular disease.
| Cell Type | ROS-Induced ROS Release | Response or Function | Reference | |
|---|---|---|---|---|
| 1 | VSMC/fibroblast | H2O2-p22phox(NOX2)-ROS | Cell injury and damage | [16] |
| 2 | adipose arterioles | Nox2-mitoROS | Flow-induced dilation | [23] |
| 3 | VSMCs | Nox1-mitoROS | AngII-induced senescence | [108] |
| 4 | leukocytes or aorta | p47phox (NOX2)-mitoROS | AngII-induced hypertension | [111] |
| 5 | VSMC | MitoROS-Nox1-ROS | Ang II-induced NOX activation | [112] |
| 6 | EC | Nox2-mitoROS | AngII-induced hypertension | [110] |
| 7 | EC | Nox4-Nox2-ROS | EC migration (angiogenesis) | [65] |
| 8 | EC | Rac1 (NOX2)-mitoROS | EC migration (angiogenesis) | [98] |
| 9 | EC | Nox4-Nox2-mtROS | Angiogenesis | [13] |