Table 4.
Pharmacokinetic parameters of tilmicosin after oral administration of tilmicosin granules and premix (Mean ± SD, n = 6).
| Parameter | Unit | Enteric Granules | Premix |
|---|---|---|---|
| Vz F | mL/kg | 234,913.52 ± 50216.91 | 212,708.7 ± 54,024.98 |
| MRT | h | 13.13 ± 4.78 | 10.73 ± 5.79 |
| AUC0-last | µg·h·mL−1 | 23.17 ± 4.12 | 8.50 ± 3.23 |
| T1/2β | h | 9.10 ± 3.31 | 7.44 ± 4.02 |
| CL | L/h/kg | 8203.84 ± 1374.71 | 23,895.02 ± 8991.91 |
| Tmax | h | 2 ± 0 | 4.0 ± 1.26 |
| Cmax | µg/mL | 2.11 ± 0.62 | 0.92 ± 0.04 |
| F (%) | / | 272.46% | / |
AUC0–last: area under the curve; CL: body clearance; T1/2β: elimination half-life; MRT: mean residence time; Cmax: peak concentration; Tmax: the time reach to the peak concentration; F: relative bioavailability.