Table 1.
Compositions of oxaliplatin-loaded multivesicular liposome (MVL) depot formulations. HSPC: hydrogenated soybean phosphatidylcholine, DEPC: 1,2-dierucoyl-sn-glycero-3-phosphocholine, DSPG-Na: 1,2-disteraroyl-sn-glycero-3-phospho-rac-glycerol-sodium salt, DSPE mPEG-2000: 1,2-distaeroyl-sn-glycero-3-phosphoehanolamine-conjugated polyethylene glycol-2000, and EE: entrapment efficiency.
| Formulation | Oxaliplatin | β-cyclodextrin | HSPC | DEPC | DSPG-Na | Cholesterol | Triolein | DSPE mPEG-2000 | Lipid Conc. | Span | % EE |
|---|---|---|---|---|---|---|---|---|---|---|---|
| mg | mM | ||||||||||
| Depot-1 | 10 | 3.5 | - | - | 1 | 10 | 1 | 1 | 13 | 5.69 | 60.0 ± 3.10 |
| Depot-2 | 5 | - | 1 | 10 | 1 | 1 | 18 | 4.87 | 66.1 ± 1.15 | ||
| Depot-3 | - | 10 | 1 | 10 | 1 | 1 | 23 | 2.27 | 77.96 ± 2.05 | ||
| Depot-4 | 10 | 10 | 1 | 5 | 1 | 1 | 28 | 2.08 | 79.95 ± 1.27 | ||
| Depot-5 | 10 | 10 | 1 | 10 | 1 | 1 | 33 | 1.99 | 92.16 ± 2.17 | ||
| Depot-6 | 10 | 10 | 1 | 10 | 5 | 1 | 37 | 2.66 | 73.17 ± 3.97 | ||
| Depot-7 | 10 | 10 | 5 | 10 | 1 | 1 | 37 | 3.05 | 84.19 ± 3.09 | ||