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. 2020 Jul 24;9(8):1770. doi: 10.3390/cells9081770

Figure 1.

Figure 1

Dose-dependent effects of S1P on coronary flow of isolated murine hearts infused alone or in the presence of S1P-carrier albumin. In these experiments S1P was applied in a range of 10−9 to 10−5 M in cumulative doses without (S1P) or in the presence of its carrier, human serum albumin (S1P + albumin), and its effects on coronary flow were investigated. Albumin was present in a concentration twice that of S1P. ED50 values were 1.17 × 10−6 M (S1P) and 1.85 × 10−7 M (S1P + albumin). Mean ± SEM; n = 9; 8. Non-linear regression analysis and comparison of Fits using GraphPad Prism 7.0.