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. 2020 Aug 9;25(16):3623. doi: 10.3390/molecules25163623

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The schematic diagram representing AIMs potentiating CDDP sensitivity through NF-κB inhibition. In this study, CDDP resistance of MCF-7 cells was at least in part involved in Akt activation and NF-κB activation; CDDP significantly increased p-Akt and followed by maintaining p-NF-κB, and p-IκB which are usually suppressed by CDDP in CDDP-sensitive cancer cells [15]. AIMs inhibited CDDP-induced Akt activation and suppressed maintained NF-κB activity. Through these two mechanisms, AIMs enhanced CDDP efficacy of MCF-7 cells that showed relative resistance by X-linked inhibitor of apoptosis protein (XIAP). AIMs contains the following composition; delphinidin-3,5-diglucoside:cyanidin-3,5-diglucoside:petunidin-3,5-diglucoside:delphinidin-3-glucoside:malvdin-3,5-diglucoside:peonidin-3,5-diglucoside: cyanidin-3-glucoside:petunidin-3-glucoside:peonidin-3- glucoside:malvidin-3-glucoside ¼ 1.0:0.5:3.4:28.1:6.4:6.4:4.2: 2.5:4.9:22.5:5.0:22.6.