Figure 4.

Excessive engraftment of CD34⁺ cells might cause graft vs. host disease (GvHD)-like symptoms. One of the mice showed signs of GvHD. First, a weight loss of 20% in less than a week (A). In addition, a decrease in the number of hCD45⁺ in peripheral blood (B) and reduced haematopoietic tissue in the BM, as compared with other mice (C). The spleen size was enlarged, and more hCD45⁺ infiltration occurred, which could have affected the spleen tissue (D). Scale bars: 200 µm. BW: body weight, G3-M1: group 3, mouse 1.