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. 2020 Jul 24;10(8):1441. doi: 10.3390/nano10081441

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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BBB transport pathways. A schematic diagram of endothelial cells (ECs), pericytes, and astrocytes forming the BBB. (A) The activity of efflux transport proteins such as p-glycoprotein (P-gp). (B) Selective permeability of tight BBB. (C) Carrier mediated pathway. (D) Passive transportation. (E) Receptor mediated pathway. (F) Adsorptive mediated pathway. (G) Natural occurring biomolecules increase the permeability of the brain endothelium. Reproduced from “Advanced in Microfluidic Blood-Brain Barrier (BBB) Models”, with permission from Elsevier, 2019.