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. 2020 Jul 24;10(8):1441. doi: 10.3390/nano10081441

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) Preparation of siRNA-RA NPs. (b) Knockdown the expression level of SOX-9 mRNA. (c) The latency in target quadrant in Morris water maze (MWM). (d) Representative in vivo T₂ MRI images of brains with PHEMA-RA-PCB-CPP/SPIONs/siSOX-9 NPs. (S1) wild, (S2) PBS, (S3) NSCs alone, (S4) PHEMA-RA-PCB-CPP/SPIONs/si-nonsense NPs NSCs, (S5) PHEMA-PCB-C PP/RA/SPIONs/siSOX-9 NPs NSCs, (S6) PHEMA-RA-PEG-CPP/SPIONs/siSOX-9 NPs NSCs, (S7) PHEMA-RA-PCB/SPIONs/siSOX-9 NPs NSCs, and (S8) PHEMA-RA-PCB-CPP/SPIONs/siSOX-9 NPs NSCs. * p < 0.05, ** p < 0.01, and *** p < 0.005 (n = 5) versus control. Reproduced from “Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer’s Disease Therapy”, with permission from John Wiley and Sons, 2016.