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. 2020 Aug 19;10:1438. doi: 10.3389/fonc.2020.01438

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Copyright © 2020 Lu, Betancur, Chen and ter Meulen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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G100 inflames TME of A20 tumors. (A) A20 tumors (n = 4 mice/group) treated with G100 (10 μg/ml GLA, 2%SE) for 1 week (3 injections, every other day) were collected for gene expression analysis by Nanostring. Multiple immune response pathways, including type 1 interferon signaling, DC function, T cell, and NK cell functions, were all activated. (B) Tumor infiltrating lymphocytes (TIL) were collected for Flow cytometry analysis and stained with antibodies for CD3, CD4, CD8, Foxp3, and NKp46. G100 treatment induced significant increase in T cells and NK cells and a decrease in T_reg among CD4 T cells. SE treatment was no different from PBS control in any of the markers. (C) Gene expression levels of T cell exhaustion markers in G100-treated and non-treated tumors (n = 4 mice/group). *p < 0.05 by student t-test.