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. 2020 Aug 19;10:1348. doi: 10.3389/fonc.2020.01348

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Copyright © 2020 Omran, Abdelfattah, Moussa, Alieldin and Shouman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relations express the relation between response and pharmacokinetic parameters. (A) Plasma IM trough concentration (ng/ml) (P = 0.006), (B) IM peak/trough ratio (P/T) (P = 0.001), (C) Elimination rate constant (K_e) (P = 0.001), (D) IM clearance (ml/min) (P = 0.004), (E) Plasma trough of Pyridine-N-oxide imatinib (P = 0.01), and (F) Peak/Trough ratio (P/T) Pyridine-N-oxide imatinib (P = 0.008).