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. 2020 Aug 19;8:783. doi: 10.3389/fcell.2020.00783

FIGURE 6.

FIGURE 6

Viral response genes in first trimester syncytiotrophoblasts and second trimester extravillous trophoblasts. (A) Heatmap showing the expression of genes involved in viral response in ACE2- and TMPRSS2-positive (ACE2 + TMPRSS2 +) cells of first trimester STB (n = 9) and second trimester EVT (n = 29). Each row is a gene and each column represents data for a single ACE2 and TMPRSS2 co-expressing cell. (B) Cluster dendrogram of first trimester STB and second trimester EVT cells. The horizontal axis of the dendrogram represents the distance or dissimilarity between clusters. The vertical axis represents the clusters. (C) Mean of four clusters of upregulated genes in first trimester STB and second trimester EVT cells. Y axis represents cluster mean expression and X axis represents different cell types. (D) Pathways enriched in the in four clusters of first trimester STBs and second trimester EVTs, with their enrichment score and p-values. EVT, extravillous trophoblast; STB, syncytiotrophoblast. Data was extracted from single cell RNA-seq of human placenta (Liu et al., 2018) [Accession number GSE89497].