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. 2020 Aug 19;11:1258. doi: 10.3389/fphar.2020.01258

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Copyright © 2020 Saha, Sharma, Singh, Samanta, Bhakta, Mandal, Bhattacharya, Lee and Chakraborty

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The life cycle of SARS-CoV-2 is shown. Various steps in the life cycle are mentioned—receptor binding of the virus, fusion with the host membrane, viral RNA release, translation of viral RNA, proteolysis of the proproteins, replication and translation, packaging of viral particles, and virion release. Possible targets of various antiviral drugs that are being repurposed/investigated for COVID-19 are indicated. S, spike protein; E, envelope protein; M, membrane protein; N, nucleocapsid protein; HCQ, hydroxychloroquine, ER, endoplasmic reticulum; ERGIC, ER-Golgi intermediate compartment.