TABLE 3.

Biofilm eradication concentrations for parent and passaged bacteria.

Bacterium	Antibiotics	MBEC (mg/l)
		P0	P10	X10
S. aureus WIBG 1.2	Ciprofloxacin	62.50	31.30	31.30
	Vancomycin	62.50	62.50	62.50
S. aureus WIBG 1.6	Ciprofloxacin	62.50	62.50	62.50
	Vancomycin	125	31.30	62.50
	Ampicillin	16000	4000	2244 (816)
MRSA	Ciprofloxacin	15.60	15.60	15.60
	Vancomycin	15.60	62.50	62.50
	Ampicillin	ns	ns	ns
S. epidermidis	Ciprofloxacin	7.81	11.03 (4.26)	7.81
	Vancomycin	62.50	31.25	62.50
S. pyogenes	Ciprofloxacin	3.90	3.90	3.90
P. aeruginosa WIBG 1.3	Ciprofloxacin	7.81	7.81	7.81
	Gentamicin	125	500	125
	Meropenem	31.30	15.60	15.60
P. aeruginosa WIBG 2.2	Ciprofloxacin	3.90	3.90	4.37 (1.59)
	Gentamicin	15.60	125	15.60
	Meropenem	2.76 (1.07)	3.90	3.90
E. coli WIBG 2.4	Ciprofloxacin	0.98	0.49	0.98
	Gentamicin	250	125	125
	Meropenem	0.98	0.98	0.69 (0.27)

Bold type indicates a ≥ 4-fold change when comparing baseline sensitivities (P0) to P10 and X10 values. Data are expressed as geometric means from biologically duplicated experiments, with each comprising technical triplicates. Standard deviations are given in the parentheses if the data varied between replicates. Non-susceptible (ns) denotes no sensitivity breakpoint determined as the value was in excess of the antimicrobial concentrations used in the broth dilution.