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. 2020 Aug 19;8:999. doi: 10.3389/fbioe.2020.00999

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Copyright © 2020 Lei, Cheng, Lin, Pang, Yao, Chen, Forouzanfar, Bikker, Wu and Cheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histological evaluation of epidermal thickness at wound sites. (A) 7 days post-surgery, the newly formed epidermal in the 10 μM Hst1 group was thicker and cell stratification was more obvious. The yellow curve showed the epidermal regeneration area. The scale bar = 500 μm; (B) Quantitative analysis showed that the treatment with 10 μM Hst1 was associated with the highest thickness of newly formed epidermal layer, which was followed by ADM + 10 μM Hst1. In contrast, ADM alone didn’t promote epidermal thickness. §: The 10 μM Hst1 group and 10 μM Hst1 + ADM group vs the control group; *: The 10 μM Hst1 group and 10 μM Hst1 + ADM group vs the ADM group; –Y: The 10 μM Hst1 group vs the 10 μM Hst1 + ADM group (P < 0.05).