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. 2020 Aug 19;8:999. doi: 10.3389/fbioe.2020.00999

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Copyright © 2020 Lei, Cheng, Lin, Pang, Yao, Chen, Forouzanfar, Bikker, Wu and Cheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemical evaluation of angiogenic marker VEGF positive expression. (A) 14 days post-surgery, the positive expression level of VEGF (in green arrows) in the 10 μM Hst1 group was higher. The scale bar = 50 μm. (B) Quantitative analysis of the VEGF expression level at wound sites. 14 days post-surgery, the VEGF expression in the groups of 10 μM Hst1 and ADM + 10 μM Hst1 was significantly higher compared with the control group and ADM group. §: The 10 μM Hst1 group and 10 μM Hst1 + ADM group vs the control group (P < 0.05).