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. 2020 Aug 19;11:546. doi: 10.3389/fendo.2020.00546

Figure 1.

Figure 1

Hypertensive rat model validation. (A) Systolic and diastolic blood pressure (SBP and DBP) and (B) Heart rate values in WKYR and SHR 8 months old. (C) Heart weight/tibia length ratio as heart size parameter at protocol ending. (D) H&E staining, cardiomyocyte area and (E) myosin heavy chain 7 (Myh7) and (F) Titin (Ttn) expression as hypertrophy parameters in WKYR compared with SHR. (G) Masson's trichrome staining to determine interstitial fibrosis in SHR compared with WKYR after training. (H,I) Systolic and diastolic blood pressure at beginning (Baseline) and ending (Post-training) in WKYR and SHR. Groups: WYKR untrained (n = 8), WYKR trained (n = 8), SHR untrained (n = 10) and SHR trained (n = 10). All values are mean ± SD. Statistical significance was calculated using ANOVA, and group comparisons were performed using Tukey's test. *p < 0.05 untrained vs. trained group, **p < 0.01 untrained vs. trained group, #p < 0.05, ###p < 0.001, and ####p < 0.0001 WKYR vs. SHR. Circles and triangles correspond to outlier data in WKYR and SHR, respectively.